= Solution
The <liposomes> could be separated from free <proteins> by <density-gradient flotation>: lipid-containing particles float to a different position from soluble <protein>. <Size-exclusion chromatography> is another possibility if it resolves the large vesicles from the unincorporated <proteins>. Simple sedimentation can also collect sufficiently large vesicles, but <protein> aggregates may sediment too. The important control is to show that the recovered <SNARE proteins> associate with the <lipid bilayer>, rather than merely copurifying with it.
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