= Solution
\b[V3 is a plausible responsive partner; V8 is less likely to show the same stimulation.] V3 conserves the aligned S/E and S/Q pairs implicated by the V2 comparisons, whereas V8 differs at those positions. This supports a prediction of conserved recognition, not a conclusion that sequence identity guarantees the same kinetic response.
Other residues, <protein> folding, <lipid bilayer> orientation and partner compatibility matter too. In particular, comparing the aligned motifs is more informative here than comparing only the variable N-terminal tails. The prediction should be checked by equivalent functional comparisons, rather than inferred from the family names alone.
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