Solution
= Solution
Read the ten residue–residue columns from the <BLOSUM62> <substitution matrix>. In their order in the supplied <sequence alignment>, their contributions are
$$
-2+4+0-2-1+2+5+5+6+7=24.
$$
There are three gap positions, each incurring the stated <linear gap penalty> of four, including the leading gap. Therefore \b[the alignment score is $\boxed{24-3(4)=12}$.]