= Solution
\b[<Opium> was chiefly used to relieve pain, procure sleep, suppress troublesome <cough> and restrain <diarrhoea>; each effect can relieve suffering while also creating a hazard.] It is a mixture of <alkaloids>, not a single standardized modern drug. Preparations such as <laudanum> cannot be treated as interchangeable volumes of “a sedative”. <Morphine> and <codeine> account for important pharmacological effects, but historical extracts varied.
For pain, the useful objective is relief sufficient for rest and function. A person exhausted by severe pain may sleep after analgesia; that is different from using ever-increasing sedation to suppress an unexplained illness. In an 1866 explanation, <opium> might therefore accompany treatment of painful inflammatory disease or severe colic. It could palliate suffering even when no curative treatment existed. It did not follow that a quieter person had recovered from <pericarditis>, obstruction or <infection>.
For <cough>, reducing an exhausting, unproductive symptom was the historical aim. But suppressing a protective <cough> where clearance of secretions or maintenance of breathing is already impaired can be harmful. For <diarrhoea>, slowing intestinal transit reduces the number of stools; it does not restore lost fluid or eliminate an infectious cause. The modern pharmacological description of <opium tincture> specifically links its antidiarrhoeal effect to altered <intestinal motility> and greater absorption of <water> from intestinal contents.<Opium tincture in the NCI Drug Dictionary>[Definition and mechanism as an antidiarrhoeal agent]{ref} Reduced output is therefore not by itself proof that the underlying disease is improving.
Historical uses also extended to spasmodic disorders and states called nervous excitement. These broad categories mixed different causes. A drug producing drowsiness could conceal deterioration, and neither <tetanus> nor <alcohol withdrawal> becomes adequately treated merely because the person is less visibly agitated. The contemporary medical debate openly questioned when <opium> was useful in such different conditions as <delirium tremens>, <dysentery> and <cholera>.<Introductory Address at the Public Opening of the Medical Session, 1866–67 by William Tennant Gairdner>[p. 294, disputed indications for opium in delirium tremens, dysentery and cholera]{ref}
\b[Modern correction: use a defined drug for a defined indication, with monitoring of benefit and toxicity.] Properly prescribed <opioids> remain important for selected severe pain and palliation; crude <opium> is not a general remedy for sleeplessness, agitation or an undiagnosed abdomen. Major hazards include <respiratory depression>, excessive sedation, <nausea>, <constipation>, physical dependence and harmful interactions with other depressant drugs. Extra care is needed with renal or hepatic impairment. <Gastrointestinal obstruction>, particularly <paralytic ileus>, and significant respiratory compromise can preclude routine opioid use; the details depend on the drug and clinical setting.<Morphine by MedlinePlus>[Important warning; precautions and adverse effects]{ref}<Morphine Sulfate prescribing information (FDA)>[Contraindications; respiratory depression, gastrointestinal effects and special-risk groups]{ref} In sustained palliative treatment, review analgesia and adverse effects and anticipate <constipation>, rather than waiting for it to become severe.<Palliative care for adults: strong opioids for pain relief by NICE>[CG140, dose review, renal or hepatic impairment and recommendations 1.1.18–1.1.20 on laxatives]{ref}
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