= Perforin
A cytotoxic-lymphocyte pore-forming <protein> supporting delivery of <granzymes> during target-cell killing.
Pore formation helps <granzymes> reach the target-cell interior after cytotoxic-cell contact. This makes membrane permeabilization and the subsequent death programme distinguishable stages; detection of one effector alone does not establish that target killing was completed. <Molecular Biology of the Cell, 4th edition by Bruce Alberts and others>[Chapters 3, 6 and 15, protein function, translation and cell signalling]{ref}
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