Predicted aligned error (source code)

= Predicted aligned error
{title2=PAE}

Expected positional error at one residue after predicted and true structures are aligned on another residue. Low within-domain values with high between-domain values support more confident internal geometry than relative domain placement. PAE is not a physical residue–residue distance and need not be symmetric.<PAE: A measure of global confidence in AlphaFold2 predictions by EMBL-EBI>[Formal definition and interpretation of inter-domain confidence]{ref}