Protein aggregation
= Protein aggregation
{wiki}
<Protein aggregation> is the association of <proteins> into clusters, often involving exposed regions of partly folded or unfolded <polypeptide chains>. It can prevent recovery of normal function while leaving the <protein primary structures> intact. It is distinct from both unfolding one chain and the functional assembly described by <protein quaternary structure>. See https://www.ncbi.nlm.nih.gov/books/NBK9843/[Cooper: partly folded chains, aggregation and chaperone protection].