Protein degradation
= Protein degradation
<Protein degradation> breaks <proteins> into smaller products and helps control <protein> abundance and quality. The <ubiquitin-proteasome system> selectively targets many intracellular <proteins>, while <lysosomes> degrade other material delivered by intracellular trafficking or <autophagy>. Synthesis and removal jointly determine abundance, so reduced <protein> level need not imply reduced <transcription>. Controlled degradation also makes some regulatory changes rapid and effectively irreversible for the individual <protein> molecule. <The Cell: A Molecular Approach, 2nd edition by Geoffrey M. Cooper/Protein Degradation>[The Cell: A Molecular Approach, protein turnover, proteasomes and lysosomes]{ref}