= Protein-protein interaction network
A <protein-protein interaction network> represents <proteins> as nodes and recorded interactions as edges. Direct physical binding, membership of a larger complex and functional association are different edge meanings and should be distinguished. A highly connected node can reflect biology, experimental sampling or both. The network is useful for proposing coordinated functions, but an edge alone does not identify <binding affinity>, direction of signalling or simultaneous occupancy. <Molecular Biology of the Cell, 4th edition by Bruce Alberts and others>[Chapter 8, Studying Protein Interactions and Functions]{ref}
Back to article page
