= Protein tertiary structure
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The <protein tertiary structure> is the overall spatial arrangement of one <polypeptide chain>. It includes how its <protein secondary structures> and intervening regions fit together. For example, the schematic under <protein> places positions 4 and 9 near each other despite their separation in <protein primary structure>. Such cooperation can help construct an <active site>; sequence distance and spatial separation answer different questions. <Hydrophobicity>, <backbone hydrogen bonds> and other interactions help stabilize folds, and some <proteins> additionally contain <protein disulfide bonds>. See https://www.ncbi.nlm.nih.gov/books/NBK9879/[Cooper: tertiary structure and interactions between chain regions].
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