= R. Marini
{c}
\b[R. Marini] is a coauthor of the 1999 report \i[Functional arteries grown in vitro], a primary study of engineered vascular tissue. The paper combined cultured-vessel measurements with implantation in an animal model.<Functional arteries grown in vitro by L. E. Niklason and others>[Primary byline and abstract]{ref}
This work connects two distinct questions in <tissue engineering>: whether a construct tolerates mechanical loading and whether it functions in a biological setting. Pressure resistance, attachment at a surgical connection and the maintenance of an open flow path are different observations. Success in one test does not logically establish the others.
An illustrative <biomechanics> calculation makes the distinction concrete. For a thin cylindrical vessel wall, a <force> balance gives circumferential <stress> $\sigma_\theta\approx pr/h$, with internal pressure $p$, radius $r$ and wall thickness $h$. Chosen values $p=100\,\mathrm{kPa}$, $r=1\,\mathrm{mm}$ and $h=0.1\,\mathrm{mm}$ give $\sigma_\theta\approx1\,\mathrm{MPa}$. This is a model calculation, not a reported result or an operating recommendation. Geometry and pressure must be specified before comparing a vessel’s material response.
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