= Rab GTPase
{c}
= Rab-family GTPase
{c}
{synonym}
A <Rab GTPase> is a small GTP-binding <protein> that regulates membrane traffic. GDP- and GTP-bound states differ in their interactions with effectors, while exchange factors and GTPase-activating <proteins> regulate the cycle. Different Rabs act at different trafficking stages, helping organize compartment identity, motor recruitment and carrier targeting. <Rab8a> and <Rab11a> illustrate related switches with different preferred routes and partners. <Rab Conversion as a Mechanism of Progression from Early to Late Endosomes by Jochen Rink and others>[2005, Rab5-to-Rab7 transition and endosomal identity]{ref}
Back to article page
