RDR2 (source code)

= RDR2
{c}

An RNA-dependent <RNA polymerase> contributing to double-stranded precursors for canonical <RdDM> small <RNAs>.

Its RNA-copying activity helps convert a single-stranded <RNA> <substrate> into a double-stranded precursor for later processing. This step differs from copying <DNA> into <RNA>, which is performed by a DNA-dependent polymerase. <Metal A and metal B sites of nuclear RNA polymerases Pol IV and Pol V are required for siRNA-dependent DNA methylation and gene silencing by J. R. Haag and others>[2009, Pol IV/Pol V-dependent siRNA pathway]{ref}