= Rough endoplasmic reticulum
= RER
{c}
{synonym}
<Rough endoplasmic reticulum> bears attached <ribosomes> on its <cytosol> surface. In a common mammalian route, <protein targeting> delivers a <nascent chain> into the <ER lumen> during <biological translation>. Other <proteins> enter the membrane. Free and attached <ribosomes> share the same basic machinery; targeting depends on their cargo.<Molecular Biology of the Cell, 4th edition by Bruce Alberts and others/The Endoplasmic Reticulum>[Molecular Biology of the Cell, 4th edition by Bruce Alberts and others; Membrane-bound Ribosomes Define the Rough ER, Figures 12-36 and 12-37; Translocation Across the ER Membrane Does Not Always Require Ongoing Polypeptide Chain Elongation]{ref}
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