= S. D. Wright
{c}
<S. D. Wright> investigated how receptors of <phagocytes> connect recognition of coated targets with distinct cellular responses. With <S. C. Silverstein>, Wright compared <hydrogen peroxide> release from <granulocytes>, <monocytes> and <macrophages> spreading on surfaces coated with different ligands. The 1983 study found strong release on <IgG>-coated surfaces but little on surfaces carrying <C3b> or <iC3b>, historically written C3bi.<Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes by S. D. Wright and S. C. Silverstein>[Abstract; ligand-coated surfaces and hydrogen-peroxide measurements]{ref}
The useful mechanistic distinction was between engulfment and an oxidative response. Under conditions combining <fibronectin> with complement ligands, the cultured <monocytes> showed a strong <phagocytosis> response without measurable <hydrogen peroxide> release.<Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes by S. D. Wright and S. C. Silverstein>[Abstract; fibronectin/C3-coated surfaces and dissociation of the two outcomes]{ref} Thus receptor engagement does not specify one indivisible activation state. Measuring only uptake would miss a difference revealed by measuring a second output.
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