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Joined 2026-09-21 Message
Incoming links: S. H. DeVries
Original publisher text www.sciencedirect.com/science/article/pii/S0896627300001586 . Abstract and Results: paired cone/OFF-bipolar recordings and receptor pharmacology distinguish AMPA/kainate pathways and temporal filtering in ground-squirrel retina.
S. H. DeVries 2026-11-05
S. H. DeVries investigated how parallel pathways in the retina extract different temporal components from a shared cone cell signal. In a 2000 study, simultaneous recordings from synaptically connected cone cells and OFF retinal bipolar cells linked distinct bipolar-cell types to different AMPA receptors or kainate receptors.[ref]
Bipolar cells use kainate and AMPA receptors to filter visual information into separate channels by S. H. DeVries. Abstract; paired recordings and postsynaptic receptor differences
The glutamate signal released by one cone cell can therefore enter several postsynaptic channels with different response dynamics. The study combined paired measurements with receptor-selective pharmacology in ground-squirrel retina, making it possible to compare the input and output at an identified connection.[ref]
Bipolar cells use kainate and AMPA receptors to filter visual information into separate channels by S. H. DeVries. Original Results; cone/OFF-bipolar recordings and AMPA/kainate pharmacology
The motivating question is how the same changing light signal can support both a response to a rapid transition and a response to a more sustained change. Different receptor kinetics supply one experimentally testable part of that explanation. A common transmitter does not require identical temporal filtering in every receiving neuron; neither does a result in these cell types establish a universal receptor assignment across every species and retina.