= S. H. DeVries
{c}
<S. H. DeVries> investigated how parallel pathways in the <retina> extract different temporal components from a shared <cone cell> signal. In a 2000 study, simultaneous recordings from synaptically connected <cone cells> and <OFF retinal bipolar cells> linked distinct bipolar-cell types to different <AMPA receptors> or <kainate receptors>.<Bipolar cells use kainate and AMPA receptors to filter visual information into separate channels by S. H. DeVries>[Abstract; paired recordings and postsynaptic receptor differences]{ref}
The <glutamate> signal released by one <cone cell> can therefore enter several postsynaptic channels with different response dynamics. The study combined paired measurements with receptor-selective pharmacology in ground-squirrel <retina>, making it possible to compare the input and output at an identified connection.<Bipolar cells use kainate and AMPA receptors to filter visual information into separate channels by S. H. DeVries>[Original Results; cone/OFF-bipolar recordings and AMPA/kainate pharmacology]{ref}
The motivating question is how the same changing light signal can support both a response to a rapid transition and a response to a more sustained change. Different receptor kinetics supply one experimentally testable part of that explanation. A common transmitter does not require identical temporal filtering in every receiving <neuron>; neither does a result in these cell types establish a universal receptor assignment across every species and <retina>.
Back to article page
