= Sar1 GTPase
{c}
<Sar1 GTPase> is a small GTP-binding <protein> that initiates <COPII> coat assembly at the <endoplasmic reticulum>. Its GTP-bound state associates with the membrane and recruits the <Sec23-Sec24 complex>, followed by the <Sec13-Sec31 complex>. <Nucleotide> cycling helps coordinate coat assembly and turnover. Reconstitution with defined components demonstrates a direct role in carrier formation rather than only an indirect consequence of cellular signalling. <COPII-coated vesicle formation reconstituted with purified coat proteins and chemically defined liposomes by Ken Matsuoka and others>[1998, Sar1-dependent COPII reconstitution]{ref}
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