Sec23-Sec24 complex
= Sec23-Sec24 complex
{c}
The <Sec23-Sec24 complex> forms the inner <COPII> coat layer. <Sec24> provides cargo-recognition sites, while <Sec23> binds <Sar1 GTPase> and contributes to regulation of its <GTPase> cycle. The outer <Sec13-Sec31 complex> then organizes the coat scaffold. Distinct cargo-binding sites on <Sec24> explain how one coat can capture different cargo classes rather than relying on a single universal recognition sequence. <Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles by Elizabeth A. Miller and others>[2003, cargo-binding-site mutations and transport selectivity]{ref}