= Selective methyl labelling
Isotopic labelling of selected <methyl groups> to provide sensitive <NMR> probes in a relatively sparse spin network.
<Methyl groups> provide several equivalent <hydrogen> nuclei and can remain useful reporters in large molecular assemblies. Selecting a subset reduces spectral crowding, while isotope substitution elsewhere can reduce unwanted interactions. The observed signal identifies labelled sites rather than every part of the <protein> equally. <Structure of fully protonated proteins by proton-detected magic-angle spinning NMR by Loren B. Andreas and others>[2016, isotopic labelling and spectral sensitivity context]{ref}
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