= Stress response
A <stress response> is a coordinated change in cellular activity caused by conditions that threaten normal function, such as excessive <temperature>, nutrient shortage or damaged <proteins>. It can alter <gene expression>, <protein degradation> and <metabolism>. For example, increased production of <molecular chaperones> helps handle unfolded <proteins>. The response is protective only within limits: prolonged or severe stress can cause <cell death>. Measuring response markers therefore establishes detection of stress, not necessarily successful recovery. <Molecular Biology of the Cell, 4th edition by Bruce Alberts and others>[Chapter 6, From RNA to Protein: protein folding and quality control]{ref}
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