After relabelling the chemicals if necessary, take and . At least one diagonal entry must be positive because , whereas their sum is negative. Since their product is negative and , the off-diagonal product must be negative and sufficiently large in magnitude. The two possibilities areIn the first, activates its own production and stimulates , while suppresses : an activator-inhibitor mechanism. In the substrate-depletion pattern mechanism, promotes the autocatalytic species , which consumes or suppresses : a substrate-depletion mechanism. These are different biological interaction signs, not merely two drawings of the same feedback. Suitable relative magnitudes and sufficiently different diffusivities are still required; the sign pattern alone does not guarantee a Turing instability.