TEM-1
= TEM-1
{c}
A reference TEM-family class A <beta-lactamase> against which altered-spectrum variants can be compared.
It hydrolyses the beta-lactam ring of susceptible antibiotics, reducing their activity. Sequence variants can alter the <substrate> range, so improved performance against one compound need not imply a universal improvement against every beta-lactam. <Enzyme Nomenclature by the IUBMB>[EC 3.5.2.6, beta-lactamase reaction]{ref}