= Titus H. J. Huisman
{c}
\b[<Titus H. J. Huisman>] investigated <hemoglobin> variation and the different <globin> chains composing it. His university laboratory's history identifies him as a leader of <hemoglobin> research at the Medical College of Georgia.<Titus HJ Huisman Hemoglobinopathy Lab by Augusta University>[Our History]{ref}
<Titus H. J. Huisman> coauthored the 1968 chemical study distinguishing <glycine> and <alanine> at position 136 in <gamma-globin> material. That observation supported the presence of multiple sequence forms within human <fetal hemoglobin>.<Evidence for multiple structural genes for the gamma chain of human fetal hemoglobin by W. A. Schroeder and others>[Primary byline; page 537, opening paragraph]{ref} It was evidence from <protein> chemistry, rather than direct sequencing of the modern <HBG1> and <HBG2> genes.
In a 1970 report with <W. A. Schroeder> and colleagues, <Titus H. J. Huisman> followed <G-gamma globin> and <A-gamma globin> proportions in seven infants after birth. The reported G-gamma-to-A-gamma ratio changed from approximately 3:1 at birth toward 2:3 by five months.<Changes in the Nature of Human Fetal Hemoglobin During the First Year of Life by Titus H. J. Huisman and others>[Abstract and primary byline]{ref} This study connects molecular discrimination with a time-dependent biological observation, rather than treating all gamma chains as one unchanging category.
An original accounting example shows why a ratio is not an absolute production rate. A 3:1 ratio corresponds to G-gamma and A-gamma fractions $3/4$ and $1/4$; a 2:3 ratio corresponds to $2/5$ and $3/5$. If a stipulated total pool falls from 100 to 20 units, the A-gamma amount falls from 25 to 12 even though its fraction rises from 0.25 to 0.60. These totals are invented for the calculation, not measured values from the paper.
The scientific distinction is useful whenever developmental changes are described by a normalized molecular signal. Sequence identity, relative abundance, absolute amount and assembly pairing remain different questions. <Gamma-chain pairing bounds from bulk composition> further shows why chain fractions alone do not identify every <fetal hemoglobin> assembly.
\Image[https://web1.augusta.edu/centers/blood-disorders/images/huisman-in-lab.png]
{title=Titus H. J. Huisman pictured in his laboratory}
{description=The named photograph supplied by Augusta University's Titus HJ Huisman Hemoglobinopathy Lab, Our History section. The image remains externally hosted.}
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