= trans-Golgi network
= TGN
{c}
{synonym}
The <trans-Golgi network> is the sorting and export region at the trans side of the <Golgi apparatus>. Onward traffic can supply the <cell membrane>, <secretory granules>, or the <lysosome> route.<The Cell: A Molecular Approach, 2nd edition by Geoffrey M. Cooper/The Golgi Apparatus>[The Cell: A Molecular Approach, 2nd edition by Geoffrey M. Cooper; Protein Sorting and Export from the Golgi Apparatus, Figure 9.27 and lysosomal targeting discussion]{ref}
Processing and sorting answer different questions. In a constructed example, two cargo <proteins> could receive the same <carbohydrate> modification yet carry different targeting information and leave in different <transport vesicles>. Conversely, two chemically different cargo <proteins> could share a destination. A processing readout alone therefore cannot establish the final address; an experiment must also identify cargo location or delivery. Return traffic and retention likewise matter: the <Golgi apparatus> is a working compartment, not merely a one-way queue that empties all of its <enzymes> into outgoing carriers.
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