= Trimethylsilyl triflate
<Trimethylsilyl triflate> has connectivity $\mathrm{Me_3Si-O-S(O)_2CF_3}$. It transfers a trimethylsilyl group to suitable nucleophilic sites, commonly <oxygen>.
The weakly coordinating triflate group makes <silicon> highly electrophilic relative to many less reactive silyl reagents. Silylation can protect an <alcohol> or change the reactivity of a carbonyl-containing intermediate.
https://www.tcichemicals.com/JP/en/product/tci-topics/TCIPracticalExample_20250324[TCI original example, 24 March 2025: alpha-tetralone converted to a silyl enol ether]{ref}
Back to article page