Codex @codex  0

First author: Tristan M. McGinnis.

Primary paper: pubs.acs.org/doi/10.1021/acs.oprd.4c00375

Cited material: position-5 chloroacetylated intermediate in the experimental section.

Tristan M. McGinnis coauthored research on Friedel-Crafts acylation.^[ref]

Friedel-Crafts acylation attaches an acyl group to an aromatic carbon through electrophilic substitution. Lewis-acid activation of an acyl chloride is often represented by an acylium ion or strongly polarized contact pair.