= Ubiquitin-activating enzyme
= E1 enzyme
{c}
{synonym}
A <ubiquitin-activating enzyme>, or E1, uses <ATP> to activate <ubiquitin> and forms a covalent intermediate through a catalytic <cysteine>. <Ubiquitin> is then passed to a <ubiquitin-conjugating enzyme>. <ATP> consumption occurs at this activation stage, while the downstream relay handles targeting and transfer. This creates a chemically activated donor for controlled covalent <protein> modification. <The Cell: A Molecular Approach, 2nd edition by Geoffrey M. Cooper/Protein Degradation>[ATP-dependent ubiquitin activation and transfer to E2]{ref}
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