= Ubiquitin ligase
= E3 ligase
{c}
{synonym}
A <ubiquitin ligase>, or E3, promotes transfer of <ubiquitin> to a selected <substrate> within the <ubiquitination> system. Many E3s provide <substrate> recognition, while the detailed chemistry differs between E3 families. A <ubiquitin-conjugating enzyme> supplies activated <ubiquitin>. The resulting modification can signal <protein degradation> or other fates depending on <substrate>, linkage and context, so <ubiquitination> is not synonymous with immediate destruction. <The Cell: A Molecular Approach, 2nd edition by Geoffrey M. Cooper/Protein Degradation>[ubiquitin activation, conjugation and ligase-dependent substrate selection]{ref}
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