UPF1 (source code)
= UPF1
{c}
<UPF1> is an ATP-dependent <RNA> helicase and central regulatory factor in <nonsense-mediated decay>. Its <nucleotide> cycle, interactions and <phosphorylation> help couple recognition of an inappropriate termination context to <RNA> remodelling and degradation. <UPF2> can regulate its activity, while other factors recruit downstream decay functions. Because <UPF1> also participates in additional <RNA> processes, a perturbation <phenotype> is not automatically attributable to one decay pathway alone. <Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon by Jens Lykke-Andersen and others>[2000, identification and functional testing of human UPF factors]{ref}
Back to article page
