UPF2 (source code)
= UPF2
{c}
<UPF2> is an <adaptor protein> in <nonsense-mediated decay> that interacts with <UPF1> and <UPF3>. These interactions help couple the context of an RNA-protein assembly to activation of the decay pathway. The role is regulatory and organizational rather than simply recognizing a particular three-base <stop codon> in isolation. Different <substrates> can depend differently on individual surveillance components. <Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon by Jens Lykke-Andersen and others>[2000, UPF protein interactions and tethering-dependent decay]{ref}
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