Sodium chloride and water transport in the medullary thick ascending limb of Henle. Evidence for active chloride transport by Antonino S. Rocha and Juha P. Kokko 2026-11-05
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Journal of Clinical Investigation52(1973),612–623; DOI10.1172/JCI107223. Publisher verifies both full bylines. Abstract: isolated perfused rabbit medullary thick ascending limb; net fluid transport remained near zero under imposed osmotic gradients, while tubular NaCl concentration fell. The historical chloride-pump interpretation is not adopted as a complete modern molecular mechanism.
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