C. A. Smith and colleagues, Science 248(4958), 1019–1023, 25 May 1990. DOI 10.1126/science.2160731. The primary abstract describes direct expression screening of a human lung fibroblast cDNA library with radiolabeled TNF-alpha, a predicted 461-amino-acid integral membrane receptor, TNF-beta binding and a cysteine-rich extracellular region. The first author remains initial-only as printed.