Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase by C. Tuerk and L. Gold 2026-11-05
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Science 249(4968), 505–510 (3 August 1990), DOI 10.1126/science.2200121. Primary indexed bylines C Tuerk and L Gold, retained without inferring full given names. Abstract describes alternating RNA-binding selection and amplification, with an eight-base randomized region giving 65,536 possible sequences.
Additional primary abstract observation: two selected RNA sequences, one the wild type and one differing at four positions, had equivalent binding constants to T4 DNA polymerase. This supports the distinction between sequence identity and measured binding function. pubmed.ncbi.nlm.nih.gov/2200121/ . The indexed university-hosted original first page courses.cs.duke.edu/spring08/cps296.4/papers/TG90.pdf prints full bylines Craig Tuerk and Larry Gold; direct PDF access returned 403. Current initial-only person/source headings were preserved.
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