A DNA enzyme that cleaves RNA by Ronald R. Breaker and Gerald F. Joyce 2026-11-05
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Primary paper, Chemistry & Biology 1(4), pp. 223–229, December 1994; DOI 10.1016/1074-5521(94)90014-0. Publisher byline verifies Ronald R. Breaker and Gerald F. Joyce. Abstract Results reports selection from a randomized DNA population, lead-dependent cleavage, five selection rounds and an intermolecular catalyst with turnover rate about one per minute. Publisher record: www.sciencedirect.com/science/article/pii/1074552194900140 . The PubMed record contains an anomalous separate collective-author entry; it is not treated as an additional verified author.
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Mechanism and utility of an RNA-cleaving DNA enzyme by S. W. Santoro and G. F. Joyce 2026-11-05
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Primary research, Biochemistry 37(38), 13330–13342 (1998), DOI 10.1021/bi9812221. Indexed original byline S. W. Santoro and G. F. Joyce. Abstract reports cleavage kinetics and substrate-binding limitation of catalytic efficiency. This result does not establish universal product-release limitation. The serial-step calculation in the article is an independent model.
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