Wilbert Aarnoudse and colleagues, Journal of the American College of Cardiology 50(24), 2294–2304 (2007), DOI doi.org/10.1016/j.jacc.2007.08.047 . Primary byline and abstract, Methods: continuous saline infusion with an infusion catheter and pressure/temperature-sensing guidewire; validation in five dogs and 35 patients. The method estimates volumetric flow, not blood oxygen content.