Source: /cirosantilli/e-coli-genome-starting-point

= E. Coli genome starting point

The conventional starting point is not at the <E. Coli K-12 MG1655 origin of replication>.[] explains:
\Q[This site is the origin of replication of the E. coli chromosome. It contains the binding sites for DnaA, which is critical for initiation of replication. Replication proceeds bidirectionally. For historical reasons, the numbering of E. coli's <circular chromosome> does not start at the <origin of replication>, but at the origin of transfer during conjugation.]
If it is a bit hard to understand what they mean by "origin of transfer" though, as that term is usually associated with the <origin of transfer> of <bacterial conjugation>.