= E. Coli K-12 MG1655 operon thrLABC
{c}
Contains the <genes>: <e. Coli K-12 MG1655 gene thrL>, <e. Coli K-12 MG1655 gene thrA>, <e. Coli K-12 MG1655 gene thrB> and <e. Coli K-12 MG1655 gene thrC>, all of which have directly linked functionality.
We can find it by searching for the species in the <BioCyc promoter database>. This leads to: https://biocyc.org/group?id=:ALL-PROMOTERS&orgid=ECOLI[].
By finding the first <operon> by position we reach: https://biocyc.org/ECOLI/NEW-IMAGE?object=TU0-42486[].
That page lists several components of the promoter, which we should try to understand!
Some of the <transcription factors> are <proteins>:
* <e. Coli K-12 MG1655 gene arcA>
* <e. Coli K-12 MG1655 gene fnr>
* <e. Coli K-12 MG1655 gene dksA>
* <e. Coli K-12 MG1655 gene lrp>
After the first gene in the codon, thrL, there is a <rho-independent termination>. By comparing:
* https://biocyc.org/ECOLI/NEW-IMAGE?object=TU0-42486
* https://biocyc.org/ECOLI/NEW-IMAGE?object=TU00178
we understand that the presence of <threonine> or <isoleucine> variants, L-threonyl and L-isoleucyl, makes the <rho-independent termination> become more efficient, so the control loop is quite direct! Not sure why it cares about <isoleucine> as well though.
TODO which factor is actually specific to that DNA region?
Back to article page