= Ion channel hypothesis of Alzheimer's disease
{wiki=Ion_channel_hypothesis_of_Alzheimer's_disease}
The Ion Channel Hypothesis of Alzheimer's Disease (AD) suggests that dysfunction in ion channels, which are crucial for maintaining the balance of ions across cell membranes, plays a significant role in the pathogenesis of AD. This hypothesis posits that the dysregulation of calcium (Ca²⁺) homeostasis, due to altered function or expression of ion channels, contributes to the neuronal cell death and synaptic dysfunction observed in Alzheimer's patients.
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