= Matched molecular pair analysis
{wiki=Matched_molecular_pair_analysis}
Matched Molecular Pair Analysis (MMPA) is a chemoinformatics technique used primarily in drug discovery and medicinal chemistry to study the effects of small structural changes on the biological activity of compounds. The method involves comparing pairs of molecules (matched pairs) that differ by a specific, small modification—such as the addition, removal, or alteration of a single atom or functional group.
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