Source: wikibot/mcdonald-kreitman-test
= McDonald–Kreitman test
{wiki=McDonald–Kreitman_test}
The McDonald–Kreitman test is a statistical method used in evolutionary biology to assess the role of natural selection versus neutral evolution in shaping genetic variation within a population. Developed by biologists Brian McDonald and David Kreitman in the 1990s, the test compares the ratio of synonymous to nonsynonymous substitutions in a particular gene or set of genes.