Bridged nucleic acid

ID: bridged-nucleic-acid

Bridged nucleic acids (BNAs) are a class of modified nucleic acids that feature a bridged structure, which typically consists of a linkage between the 2' and 4' positions of the ribose sugar in RNA or the corresponding positions in DNA. These modifications enhance the stability of the nucleic acid strands against nucleases and contribute to increased binding affinity with complementary strands.

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