First proper nearest galaxy to the Milky Way. Everything in the middle in the Local group is either a satellite of the Milky Way or Andromeda.
Many Andromeda satellite galaxies are simply numbered Andromeda II, Andromeda III and so on.
As described on Wikipedia, the observational history of Andromeda is fascinating. Little by little, people noticed that it had a different nature to many other objects observed on the sky, and the hypothesis that there are other galaxies like ours grew in force.
Part of our fascination with Andromeda is due to how similar in size and shape and close it is to the Milky Way.
It is clearly the only thing so large and so close.
Andromeda is, without a doubt, our sister galaxy.