Dynamic kinetic resolution in asymmetric synthesis

Dynamic kinetic resolution (DKR) is a strategy in asymmetric synthesis that combines enantioselective transformations with racemization processes. The goal is to selectively convert a racemic mixture of substrates into a single enantiomer, thereby increasing the yield of the desired chiral product. In a typical scenario of DKR, a racemic substrate is subjected to a catalytic reaction that preferentially transforms one enantiomer more than the other.