Hydrogen–deuterium exchange (H/D exchange) is a chemical process that involves the replacement of hydrogen atoms (H) in a molecule with deuterium atoms (D), which are isotopes of hydrogen. Deuterium has one proton and one neutron in its nucleus, while ordinary hydrogen has only one proton. This exchange is a valuable technique in various fields such as chemistry, biochemistry, and analytical science, as it can provide insights into molecular structure, dynamics, and interactions.
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