The term "Mesozoic–Cenozoic radiation" generally refers to the significant diversification of life forms that occurred during the transition from the Mesozoic Era to the Cenozoic Era, which spans roughly from 66 million years ago to the present. This period is marked by dramatic changes in the Earth's climate, the breakup of continents, and the extinction of many species, notably the non-avian dinosaurs, at the end of the Cretaceous period.

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