The National Enrichment Facility (NEF) is a site operated by the United States Enrichment Corporation (USEC) for the enrichment of uranium. Located in Piketon, Ohio, the facility is designed to produce low-enriched uranium (LEU) for use in nuclear power reactors. The NEF employs a technology known as gas diffusion, which is a process used to enrich uranium to increase the concentration of the U-235 isotope necessary for use in nuclear fuel.

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