PyClone is a computational tool designed for the analysis of heterogeneous cancer genotypes from bulk sequencing data. It is used to infer the clonal structure of tumors by analyzing variant allele frequencies in genomic data derived from cancer tissues. Specifically, PyClone incorporates a Bayesian statistical framework to model the relationships between different mutations and their prevalence across samples, allowing researchers to identify distinct clones within a tumor and understand the heterogeneity of cancer cells.
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