 An endotoxin-induced serum factor that causes necrosis of tumors by E. A. Carswell and others

Primary full-text record pmc.ncbi.nlm.nih.gov/articles/PMC433057/ . PNAS72(9),3666–3670(1975). Verified Abstract: serum from BCG-infected mice treated with endotoxin caused tumor necrosis; tests distinguished a host-derived factor from residual endotoxin; two neoplastic cell lines and mouse embryo cultures differed in toxicity. Macrophage origin is the authors' proposed interpretation, not direct identification by this experiment. Initial-only E. A. Carswell identity preserved.