Andrew J. Aguirre studied how genomic genomic copy number affects CRISPR-Cas9 screening. Targeting amplified genomic regions can produce a response independent of the targeted gene's usual function, an important distinction when interpreting whether a screening signal demonstrates a gene-specific dependency.[ref]
Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting by Andrew J. Aguirre and others. 2016, abstract and copy-number-dependent gene-independent targeting response
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